Titel: Roshan Cools, Donders Institute for Brain, Cognition and Behaviour
Startdatum: Nov 26 2018
Startzeit: 11:30 am
Endzeit: 12:30 pm
Ort: Max Planck House Lecture Hall

A failure to adapt to novel or changing environmental demands is a core feature of a wide variety of neuropsychiatric disorders as well as the normal states of stress and fatigue. I will review the neurochemistry of flexible cognitive control, which has been associated primarily with frontostriatal circuitry. Many drugs affect the functioning of this circuitry, but the direction and extent of drug effects vary across individuals and tasks. Apparently paradoxical effects are often observed, where the same medication causes both cognitive enhancement as well as cognitive side effects. I will present neurobiological research that is beginning to elucidate the nature of these contrasting effects and the factors underlying the large variability across individuals and behaviours. For example, I will illustrate how we are starting to resolve the large variability in catecholaminergic drug effects by going beyond classic models of prefrontal cortex and building on recent advances that highlight a role for the catecholamines in the flexibility-stability tradeoff as well as value-based learning and decision making. The work has considerable implications for the understanding of and treatment development for abnormalities characterized by compulsivity such as Parkinson's disease and addiction.

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