Prof. Dr. V. Narry Kim
School of Biological Sciences, Seoul National University
Director, RNA Research Center, Institute for Basic Science
Title: "MicroRNA maturation"
The Elisa Izaurralde Memorial Lecture honors the work and life of our dear colleague Professor Dr. Elisa Izauralde, Director of the Department of Biochemistry at the Max Planck Institute for Developmental Biology from 2005 to her untimely death in 2018. This years speaker, Narry Kim, will be introduced by Dr. Oliver Weichenrieder a former co-worker of Elisa Izaurralde and by Prof. Dr. Ralf Sommer, Director of the Department of Integrative Evolutionary Biology, who will say a few words on the intention of this lecture series.
Abstract: MicroRNAs (miRNAs) are regulatory noncoding RNAs of ~22 nt, which act as guide molecules in gene silencing. Biogenesis of miRNA is under tight temporal and spatial regulations, and their dysregulation is often associated with human diseases. miRNA maturation is initiated by the Microprocessor complex that is composed of DROSHA and its cofactor DGCR8/Pasha. Microprocessor serves as a gate-keeper for the miRNA pathway by selectively and precisely processing the primary transcript (pri-miRNA) to release a small hairpin called pre-miRNA. In this presentation, I will first talk about the sequencing-based multiple parallel analyses of the structures and processing patterns of human pri-miRNAs, which reveals the cis-acting features determining processing efficiency/accuracy and those allowing regulations. In the later part of my talk, I will discuss trans-acting factors that modulate miRNA maturation.
To register for the lecture and receive the joining information please email: presse-eb(at)tuebingen.mpg.de